ClinVar Miner

Submissions for variant NM_006790.3(MYOT):c.683+1G>C

dbSNP: rs2149985981
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV002021636 SCV002313025 uncertain significance Myofibrillar myopathy 3 2021-03-26 criteria provided, single submitter clinical testing In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may disrupt the consensus splice site, but this prediction has not been confirmed by published transcriptional studies. This variant has not been reported in the literature in individuals with MYOT-related conditions. This variant is not present in population databases (ExAC no frequency). This sequence change affects a donor splice site in intron 5 of the MYOT gene. It is expected to disrupt RNA splicing. Variants that disrupt the donor or acceptor splice site typically lead to a loss of protein function (PMID: 16199547), however the current clinical and genetic evidence is not sufficient to establish whether loss-of-function variants in MYOT cause disease.

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