ClinVar Miner

Submissions for variant NM_006939.4(SOS2):c.2814C>T (p.Thr938=)

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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV002890278 SCV003243491 likely benign Noonan syndrome 9 2024-10-30 criteria provided, single submitter clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp RCV003994470 SCV004812993 likely benign not specified 2024-02-19 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003916557 SCV004729962 likely benign SOS2-related disorder 2020-07-23 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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