Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Invitae | RCV001246265 | SCV001419606 | uncertain significance | Holoprosencephaly 5 | 2023-04-13 | criteria provided, single submitter | clinical testing | In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Experimental studies and prediction algorithms are not available or were not evaluated, and the functional significance of this variant is currently unknown. ClinVar contains an entry for this variant (Variation ID: 970658). This variant has been observed in individual(s) with holoprosencephaly spectrum disorders (PMID: 19955556, 22847929). The frequency data for this variant in the population databases is considered unreliable, as metrics indicate poor data quality at this position in the gnomAD database. This variant, c.1377_1382dup, results in the insertion of 2 amino acid(s) of the ZIC2 protein (p.Ala469_Ala470dup), but otherwise preserves the integrity of the reading frame. |