Submissions for variant NM_007294.3(BRCA1):c.1125A>G (p.Leu375=) (rs1060504578)

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Total submissions: 4

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Invitae	RCV000477563	SCV000560280	likely benign	Hereditary breast and ovarian cancer syndrome	2016-12-21	criteria provided, single submitter	clinical testing
Ambry Genetics	RCV000561963	SCV000661002	likely benign	Hereditary cancer-predisposing syndrome	2016-02-29	criteria provided, single submitter	clinical testing	Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
GeneDx	RCV000615329	SCV000727031	likely benign	not specified	2018-01-19	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Color	RCV000561963	SCV000910216	likely benign	Hereditary cancer-predisposing syndrome	2017-11-14	criteria provided, single submitter	clinical testing

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