ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.212+10T>G (rs80358174)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000428041 SCV000529099 likely benign not specified 2016-06-22 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000469310 SCV000560279 likely benign not provided 2016-08-25 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000428041 SCV000591251 likely benign not specified 2017-10-25 criteria provided, single submitter clinical testing
Breast Cancer Information Core (BIC) (BRCA1) RCV000112016 SCV000144659 uncertain significance Breast-ovarian cancer, familial 1 no assertion criteria provided clinical testing
Research Molecular Genetics Laboratory,Women's College Hospital, University of Toronto RCV000428041 SCV000587037 uncertain significance not specified 2014-01-31 no assertion criteria provided research

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