ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.212+4T>C (rs398122652)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000162796 SCV000213275 uncertain significance Hereditary cancer-predisposing syndrome 2016-10-14 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Insufficient or conflicting evidence
GeneDx RCV000424511 SCV000520102 likely benign not specified 2015-10-09 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000424511 SCV000591249 uncertain significance not specified 2012-11-19 criteria provided, single submitter clinical testing
Invitae RCV000638010 SCV000759490 uncertain significance Hereditary breast and ovarian cancer syndrome 2017-11-14 criteria provided, single submitter clinical testing
Counsyl RCV000662727 SCV000785493 likely benign Breast-ovarian cancer, familial 1 2017-08-22 criteria provided, single submitter clinical testing
Color RCV000162796 SCV000912057 likely benign Hereditary cancer-predisposing syndrome 2017-12-05 criteria provided, single submitter clinical testing

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