ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.2612C>G (p.Pro871Arg) (rs799917)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000221093 SCV000274433 uncertain significance Hereditary cancer-predisposing syndrome 2017-07-14 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Insufficient or conflicting evidence
GeneDx RCV000442717 SCV000515312 likely benign not specified 2017-08-08 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000463451 SCV000560221 likely benign Hereditary breast and ovarian cancer syndrome 2017-08-22 criteria provided, single submitter clinical testing
Quest Diagnostics Nichols Institute San Juan Capistrano RCV000442717 SCV000600296 uncertain significance not specified 2016-12-05 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000077111 SCV000108908 likely benign Breast-ovarian cancer, familial 1 2009-06-02 no assertion criteria provided clinical testing

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