ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.4903G>A (p.Glu1635Lys) (rs200432771)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV000509803 SCV000608213 uncertain significance Hereditary cancer-predisposing syndrome 2017-10-16 criteria provided, single submitter clinical testing Lines of evidence used in support of classification: Insufficient or conflicting evidence
Biesecker Lab/Human Development Section,National Institutes of Health RCV000034755 SCV000043154 variant of unknown significance not provided 2012-07-13 no assertion criteria provided research Converted during submission to Uncertain significance.
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario RCV000769712 SCV000901132 uncertain significance Breast and/or ovarian cancer 2016-12-28 criteria provided, single submitter clinical testing
Counsyl RCV000410023 SCV000489521 uncertain significance Breast-ovarian cancer, familial 1 2016-10-18 criteria provided, single submitter clinical testing

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