ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.5152+10A>G (rs80358114)

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Total submissions: 6
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000159890 SCV000209985 benign not specified 2014-07-29 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000465217 SCV000560233 benign not provided 2019-01-19 criteria provided, single submitter clinical testing
Color RCV000584597 SCV000688540 likely benign Hereditary cancer-predisposing syndrome 2017-09-14 criteria provided, single submitter clinical testing
Counsyl RCV000031222 SCV000784754 likely benign Breast-ovarian cancer, familial 1 2017-01-30 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000031222 SCV000053822 likely benign Breast-ovarian cancer, familial 1 2011-05-24 no assertion criteria provided clinical testing
Breast Cancer Information Core (BIC) (BRCA1) RCV000031222 SCV000145334 uncertain significance Breast-ovarian cancer, familial 1 2002-05-29 no assertion criteria provided clinical testing

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