ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.5332+20C>A (rs1057521961)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000437260 SCV000525287 likely benign not specified 2016-03-02 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000437260 SCV000591614 likely benign not specified 2017-10-25 criteria provided, single submitter clinical testing
Invitae RCV000637998 SCV000759478 likely benign Hereditary breast and ovarian cancer syndrome 2017-10-19 criteria provided, single submitter clinical testing
Color RCV000775916 SCV000910404 likely benign Hereditary cancer-predisposing syndrome 2018-02-07 criteria provided, single submitter clinical testing

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