ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.5406+17C>T (rs1057522773)

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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000429143 SCV000529394 likely benign not specified 2016-06-27 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Invitae RCV000538504 SCV000636035 likely benign Hereditary breast and ovarian cancer syndrome 2019-12-31 criteria provided, single submitter clinical testing
ARUP Laboratories, Molecular Genetics and Genomics,ARUP Laboratories RCV000429143 SCV001158925 likely benign not specified 2019-01-17 criteria provided, single submitter clinical testing
Color RCV001186519 SCV001352974 likely benign Hereditary cancer-predisposing syndrome 2015-04-27 criteria provided, single submitter clinical testing
Brotman Baty Institute,University of Washington RCV001073197 SCV001238712 not provided Breast-ovarian cancer, familial 1 no assertion provided in vitro

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