ClinVar Miner

Submissions for variant NM_007294.3(BRCA1):c.81-12dupC (rs273902789)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000459848 SCV000560295 benign not provided 2019-02-24 criteria provided, single submitter clinical testing
Color RCV000582376 SCV000688667 likely benign Hereditary cancer-predisposing syndrome 2017-09-08 criteria provided, single submitter clinical testing
GeneDx RCV000608788 SCV000730541 likely benign not specified 2017-12-11 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Breast Cancer Information Core (BIC) (BRCA1) RCV000111713 SCV000144218 uncertain significance Breast-ovarian cancer, familial 1 2003-12-23 no assertion criteria provided clinical testing

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