ClinVar Miner

Submissions for variant NM_007294.4(BRCA1):c.1706A>T (p.Asn569Ile)

dbSNP: rs1060502329
Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 3
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000471509 SCV000549274 uncertain significance Hereditary breast ovarian cancer syndrome 2016-04-01 criteria provided, single submitter clinical testing Algorithms developed to predict the effect of missense changes on protein structure and function (SIFT, PolyPhen-2, Align-GVGD) all suggest that this variant is likely to be tolerated, but these predictions have not been confirmed by published functional studies. In summary, this variant is a novel missense change that is not predicted to affect protein function. There is no indication that it causes disease, but the available evidence is currently insufficient to prove that conclusively. Therefore, it has been classified as a Variant of Uncertain Significance. This variant is not present in population databases (ExAC no frequency) and has not been reported in the literature in individuals with a BRCA1-related disease. This sequence change replaces asparagine with isoleucine at codon 569 of the BRCA1 protein (p.Asn569Ile). The asparagine residue is moderately conserved and there is a large physicochemical difference between asparagine and isoleucine.
Ambry Genetics RCV002402272 SCV002710483 uncertain significance Hereditary cancer-predisposing syndrome 2021-05-28 criteria provided, single submitter clinical testing The p.N569I variant (also known as c.1706A>T), located in coding exon 9 of the BRCA1 gene, results from an A to T substitution at nucleotide position 1706. The asparagine at codon 569 is replaced by isoleucine, an amino acid with dissimilar properties. This amino acid position is not well conserved in available vertebrate species. In addition, this alteration is predicted to be tolerated by in silico analysis. Since supporting evidence is limited at this time, the clinical significance of this alteration remains unclear.
University of Washington Department of Laboratory Medicine, University of Washington RCV002402272 SCV003851100 likely benign Hereditary cancer-predisposing syndrome 2023-03-23 criteria provided, single submitter curation Missense variant in a coldspot region where missense variants are very unlikely to be pathogenic (PMID:31911673).

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.