ClinVar Miner

Submissions for variant NM_007297.4(BRCA1):c.-8+8224C>T (rs80358006)

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Total submissions: 15
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV000123875 SCV000167220 benign not specified 2014-01-22 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Michigan Medical Genetics Laboratories,University of Michigan RCV000031283 SCV000195876 benign Breast-ovarian cancer, familial 1 2014-11-03 criteria provided, single submitter clinical testing
Counsyl RCV000031283 SCV000220259 benign Breast-ovarian cancer, familial 1 2014-04-18 criteria provided, single submitter literature only
Invitae RCV000200423 SCV000252825 benign Hereditary breast and ovarian cancer syndrome 2018-01-02 criteria provided, single submitter clinical testing
CHEO Genetics Diagnostic Laboratory,Children's Hospital of Eastern Ontario RCV000768581 SCV000324807 likely benign Breast and/or ovarian cancer 2016-01-26 criteria provided, single submitter clinical testing
Baylor Genetics RCV000463254 SCV000540989 benign Familial cancer of breast 2017-02-23 criteria provided, single submitter clinical testing
Cancer Genetics and Genomics Laboratory,British Columbia Cancer Agency RCV000123875 SCV000586863 benign not specified 2017-04-18 criteria provided, single submitter clinical testing
Department of Pathology and Molecular Medicine,Queen's University RCV000123875 SCV000588025 likely benign not specified 2017-04-20 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000123875 SCV000591235 benign not specified 2013-05-17 criteria provided, single submitter clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV000123875 SCV000602683 benign not specified 2016-09-25 criteria provided, single submitter clinical testing
Color RCV000580413 SCV000683365 benign Hereditary cancer-predisposing syndrome 2015-03-04 criteria provided, single submitter clinical testing
PreventionGenetics,PreventionGenetics RCV000679704 SCV000806985 likely benign not provided 2017-06-01 criteria provided, single submitter clinical testing
Sharing Clinical Reports Project (SCRP) RCV000031283 SCV000053888 benign Breast-ovarian cancer, familial 1 2006-02-23 no assertion criteria provided clinical testing
Breast Cancer Information Core (BIC) (BRCA1) RCV000031283 SCV000144222 uncertain significance Breast-ovarian cancer, familial 1 2002-05-29 no assertion criteria provided clinical testing
Diagnostic Laboratory, Department of Genetics,University Medical Center Groningen RCV000031283 SCV000733683 benign Breast-ovarian cancer, familial 1 no assertion criteria provided clinical testing

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