ClinVar Miner

Submissions for variant NM_007299.4(BRCA1):c.765G>A (p.Glu255=) (rs62625299)

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Total submissions: 8
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000123285 SCV000166592 benign Hereditary breast and ovarian cancer syndrome 2018-01-13 criteria provided, single submitter clinical testing
GeneDx RCV000173830 SCV000167235 benign not specified 2014-01-29 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics RCV000163053 SCV000213545 likely benign Hereditary cancer-predisposing syndrome 2014-09-18 criteria provided, single submitter clinical testing
EGL Genetic Diagnostics,Eurofins Clinical Diagnostics RCV000173830 SCV000224986 likely benign not specified 2014-10-07 criteria provided, single submitter clinical testing
Michigan Medical Genetics Laboratories,University of Michigan RCV000211047 SCV000267687 benign Breast-ovarian cancer, familial 1 2016-04-21 criteria provided, single submitter clinical testing
Baylor Genetics RCV000469425 SCV000540964 benign Familial cancer of breast 2017-02-23 criteria provided, single submitter clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV000173830 SCV000602728 likely benign not specified 2017-02-21 criteria provided, single submitter clinical testing
Color RCV000163053 SCV000683355 likely benign Hereditary cancer-predisposing syndrome 2015-10-09 criteria provided, single submitter clinical testing

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