ClinVar Miner

Submissions for variant NM_007299.4(BRCA1):c.788-899G>C (rs56214134)

Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 14
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000167802 SCV000076259 benign Hereditary breast and ovarian cancer syndrome 2018-01-05 criteria provided, single submitter clinical testing
GeneDx RCV000120295 SCV000167293 benign not specified 2014-02-05 criteria provided, single submitter clinical testing This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Michigan Medical Genetics Laboratories,University of Michigan RCV000112129 SCV000195923 benign Breast-ovarian cancer, familial 1 2014-11-03 criteria provided, single submitter clinical testing
Ambry Genetics RCV000162833 SCV000213319 benign Hereditary cancer-predisposing syndrome 2014-11-18 criteria provided, single submitter clinical testing
Counsyl RCV000112129 SCV000220665 likely benign Breast-ovarian cancer, familial 1 2014-09-03 criteria provided, single submitter literature only
Institute for Biomarker Research,Medical Diagnostic Laboratories, L.L.C. RCV000167802 SCV000576440 likely benign Hereditary breast and ovarian cancer syndrome 2017-02-14 criteria provided, single submitter clinical testing
Department of Pathology and Laboratory Medicine,Sinai Health System RCV000120295 SCV000591454 benign not specified 2014-02-03 criteria provided, single submitter clinical testing
Genetic Services Laboratory, University of Chicago RCV000120295 SCV000593673 likely benign not specified 2017-05-02 criteria provided, single submitter clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV000120295 SCV000602690 benign not specified 2016-10-18 criteria provided, single submitter clinical testing
Color RCV000162833 SCV000683114 likely benign Hereditary cancer-predisposing syndrome 2015-11-17 criteria provided, single submitter clinical testing
PreventionGenetics,PreventionGenetics RCV000120295 SCV000806936 benign not specified 2017-04-25 criteria provided, single submitter clinical testing
ITMI RCV000120295 SCV000084447 not provided not specified 2013-09-19 no assertion provided reference population
Breast Cancer Information Core (BIC) (BRCA1) RCV000112129 SCV000144802 benign Breast-ovarian cancer, familial 1 2002-05-29 no assertion criteria provided clinical testing
Foulkes Cancer Genetics LDI, Lady Davis Institute for Medical Research RCV000735466 SCV000863603 benign Breast and/or ovarian cancer 2013-11-04 no assertion criteria provided clinical testing

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.