ClinVar Miner

Submissions for variant NM_012210.4(TRIM32):c.1042G>T (p.Ala348Ser)

gnomAD frequency: 0.00001  dbSNP: rs771427815
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000695666 SCV000824180 uncertain significance Bardet-Biedl syndrome 2018-03-01 criteria provided, single submitter clinical testing In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. Algorithms developed to predict the effect of missense changes on protein structure and function do not agree on the potential impact of this missense change (SIFT: "Tolerated"; PolyPhen-2: "Benign"; Align-GVGD: "Class C25"). This variant has not been reported in the literature in individuals with TRIM32-related disease. This variant is present in population databases (rs771427815, ExAC 0.01%). This sequence change replaces alanine with serine at codon 348 of the TRIM32 protein (p.Ala348Ser). The alanine residue is moderately conserved and there is a moderate physicochemical difference between alanine and serine.

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