ClinVar Miner

Submissions for variant NM_014874.4(MFN2):c.526G>A (p.Gly176Ser)

dbSNP: rs879253862
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine RCV000235058 SCV000292352 likely pathogenic Charcot-Marie-Tooth disease type 2A2 2015-08-18 criteria provided, single submitter research Likely pathogenic based on conservation and prediction scores (Phylop, LRT, MutationTaster). Identified in homozygous state in individual with peripheral axonal neuropathy; onset at 18 months. Parents are carriers but unaffected clinically.
Labcorp Genetics (formerly Invitae), Labcorp RCV005055787 SCV005721651 uncertain significance Charcot-Marie-Tooth disease type 2 2024-06-04 criteria provided, single submitter clinical testing This sequence change replaces glycine, which is neutral and non-polar, with serine, which is neutral and polar, at codon 176 of the MFN2 protein (p.Gly176Ser). This variant is not present in population databases (gnomAD no frequency). This missense change has been observed in individuals with Charcot-Marie-Tooth disease (PMID: 26257172, 29361379). ClinVar contains an entry for this variant (Variation ID: 243074). Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) has been performed at Invitae for this missense variant, however the output from this modeling did not meet the statistical confidence thresholds required to predict the impact of this variant on MFN2 protein function. This variant disrupts the p.Gly176 amino acid residue in MFN2. Other variant(s) that disrupt this residue have been observed in individuals with MFN2-related conditions (PMID: 28286897), which suggests that this may be a clinically significant amino acid residue. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance.
Lupski Lab, Baylor-Hopkins CMG, Baylor College of Medicine RCV001007825 SCV001167517 likely pathogenic Charcot-Marie-Tooth disease, axonal, autosomal recessive, type 2a2b; no assertion criteria provided research

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