ClinVar Miner

Submissions for variant NM_014915.3(ANKRD26):c.1998A>G (p.Lys666=)

gnomAD frequency: 0.00052  dbSNP: rs372489280
Minimum review status: Collection method:
Minimum conflict level:
ClinVar version:
Total submissions: 3
Download table as spreadsheet
Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
GeneDx RCV001773144 SCV002003870 uncertain significance not provided 2021-04-06 criteria provided, single submitter clinical testing In silico analysis supports that this variant does not alter splicing; Has not been previously published as pathogenic or benign to our knowledge
Labcorp Genetics (formerly Invitae), Labcorp RCV001773144 SCV003285259 benign not provided 2023-09-04 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003976161 SCV004788439 likely benign ANKRD26-related disorder 2019-04-30 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

The information on this website is not intended for direct diagnostic use or medical decision-making without review by a genetics professional. Individuals should not change their health behavior solely on the basis of information contained on this website. Neither the University of Utah nor the National Institutes of Health independently verfies the submitted information. If you have questions about the information contained on this website, please see a health care professional.