Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Ambry Genetics | RCV004344404 | SCV004078315 | uncertain significance | not specified | 2023-06-21 | criteria provided, single submitter | clinical testing | The c.331A>G (p.K111E) alteration is located in exon 2 (coding exon 2) of the JMJD6 gene. This alteration results from a A to G substitution at nucleotide position 331, causing the lysine (K) at amino acid position 111 to be replaced by a glutamic acid (E). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear. |