ClinVar Miner

Submissions for variant NM_015978.3(TNNI3K):c.1910C>T (p.Thr637Met)

gnomAD frequency: 0.00074  dbSNP: rs2274260
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Total submissions: 3
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000899809 SCV001044097 benign not provided 2025-02-02 criteria provided, single submitter clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories RCV005231949 SCV005876971 benign Atrial conduction disease 2023-12-19 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003910725 SCV004725834 benign TNNI3K-related disorder 2024-07-10 no assertion criteria provided clinical testing This variant is classified as benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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