Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Victorian Clinical Genetics Services, |
RCV001089567 | SCV001244802 | likely pathogenic | Autosomal recessive nonsyndromic hearing loss 3 | 2018-07-31 | criteria provided, single submitter | clinical testing | A heterozygous missense variant, NM_016239.3(MYO15A):c.8162C>A, has been identified in exon 45 of 66 of the MYO15A gene. The variant is predicted to result in a moderate amino acid change from threonine to lysine at position 2721 of the protein (NP_057323.3(MYO15A):p.(Thr2721Lys)). The threonine residue at this position has moderate conservation (100 vertebrates, UCSC), and is not located within any domains. In silico predictions for this variant are consistently pathogenic (Polyphen, SIFT, CADD, Mutation Taster). The variant is absent in population databases (gnomAD, dbSNP, 1000G), and has not been previously reported in clinical cases. Based on the information available at the time of curation, this variant has been classified as LIKELY PATHOGENIC.NB: This variant has been reclassified as likely pathogenic. The presence of these two variants in transconfirms acompound heterozygous mode of inheritance which is consistent with autosomal recessive deafness. |