Total submissions: 4
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Illumina Laboratory Services, |
RCV000283316 | SCV000401217 | uncertain significance | Autosomal recessive nonsyndromic hearing loss 3 | 2018-01-12 | criteria provided, single submitter | clinical testing | This variant was observed in the ICSL laboratory as part of a predisposition screen in an ostensibly healthy population. It had not been previously curated by ICSL or reported in the Human Gene Mutation Database (HGMD: prior to June 1st, 2018), and was therefore a candidate for classification through an automated scoring system. Utilizing variant allele frequency, disease prevalence and penetrance estimates, and inheritance mode, an automated score was calculated to assess if this variant is too frequent to cause the disease. Based on the score, this variant could not be ruled out of causing disease and therefore its association with disease required further investigation. A literature search was performed for the gene, cDNA change, and amino acid change (if applicable). No publications were found based on this search. This variant was therefore classified as a variant of unknown significance for this disease. |
Laboratory for Molecular Medicine, |
RCV000600296 | SCV000712207 | benign | not specified | 2016-06-20 | criteria provided, single submitter | clinical testing | p.Gln3264Gln in exon 61 of MYO15A: This variant is not expected to have clinical significance because it does not alter an amino acid residue and is not located within the splice consensus sequence. It has been identified in 1% (89/8580) of East Asian chromosomes, including 1 homozygote, by the Exome Aggregation Consor tium (ExAC, http://exac.broadinstitute.org; dbSNP rs149189607). |
Gene |
RCV000832789 | SCV000974545 | likely benign | not provided | 2021-11-11 | criteria provided, single submitter | clinical testing | |
Invitae | RCV000832789 | SCV001022448 | benign | not provided | 2024-01-31 | criteria provided, single submitter | clinical testing |