Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Pittsburgh Clinical Genomics Laboratory, |
RCV004785025 | SCV005397452 | uncertain significance | Vissers-Bodmer syndrome | 2022-09-23 | criteria provided, single submitter | clinical testing | This sequence variant is a single nucleotide substitution (C>T) at coding position 4114 of the CNOT1 gene that results in a proline to serine amino acid change at residue 1372 of the CNOT1 protein. The Pro1372 residue falls in central coiled coil domain that interacts with CNOT9 (PMID: 33138308). This is a novel variant that is not found in an online database of clinically annotated variants (ClinVar), control populations datasets (gnomAD, 0 of approximately 250,000 alleles) or in the published literature, to our knowledge. Multiple bioinformatic tools predict that this proline to serine amino acid change would be damaging, and a proline at this position is strongly conserved across the vertebrate species examined. Studies examining the functiol consequence of this variant have not been published, to our knowledge. At this time, there is insufficient evidence to determine if this variant is pathogenic or benign. Therefore, we consider this a variant of uncertain significance. ACMG Criteria: PM2, PP3 |