Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Pittsburgh Clinical Genomics Laboratory, |
RCV004784997 | SCV005397348 | uncertain significance | Vissers-Bodmer syndrome | 2023-10-03 | criteria provided, single submitter | clinical testing | This sequence variant is a single nucleotide substitution (T>A) at position 954 of the coding sequence of the CNOT1 gene that results in a serine to arginine amino acid change at residue 318 of the CCR4-NOT transcription complex subunit 1 protein. This novel variant is absent from ClinVar, publications, and the gnomAD population database (0/~282000 alleles). Multiple bioinformatic tools predict that this serine to arginine amino acid change would be damaging, and the Ser318 residue at this position is highly conserved across the vertebrate species examined. Studies examining the functiol consequence of this variant have not been performed. Proteomic studies suggest that this serine residue is a phosphorylation target (PMID: 23186163), though the clinical significance of this is unknown. At this time, there is insufficient evidence to determine if this variant is pathogenic or benign. Therefore, we consider this a variant of uncertain significance. ACMG Criteria: PM2, PP3 |