Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Ambry Genetics | RCV002311090 | SCV000319907 | uncertain significance | Familial thoracic aortic aneurysm and aortic dissection | 2015-07-20 | criteria provided, single submitter | clinical testing | The p.K814R variant (also known as c.2441A>G), located in coding exon 15 of the NOTCH1 gene, results from an A to G substitution at nucleotide position 2441. The lysine at codon 814 is replaced by arginine, an amino acid with highly similar properties. This variant was not reported in population based cohorts in the following databases: Database of Single Nucleotide Polymorphisms (dbSNP), NHLBI Exome Sequencing Project (ESP), and 1000 Genomes Project. In the ESP, this variant was not observed in 6258 samples (12516 alleles) with coverage at this position. This amino acid position is well conserved in available vertebrate species. In addition, this alteration is predicted to be tolerated by in silico analysis. Since supporting evidence is limited at this time, the clinical significance of this variant remains unclear. |
Invitae | RCV003748214 | SCV004523877 | benign | Adams-Oliver syndrome 5 | 2023-03-18 | criteria provided, single submitter | clinical testing |