Submissions for variant NM_017636.4(TRPM4):c.1368C>G (p.Thr456=) (rs56118173)

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Total submissions: 5

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Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Invitae	RCV000227551	SCV000290316	benign	Progressive familial heart block type 1B	2017-09-28	criteria provided, single submitter	clinical testing
Illumina Clinical Services Laboratory,Illumina	RCV000306701	SCV000414293	uncertain significance	Progressive familial heart block	2016-06-14	criteria provided, single submitter	clinical testing
GeneDx	RCV000420786	SCV000532175	likely benign	not specified	2017-04-10	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Ambry Genetics	RCV000620174	SCV000735092	likely benign	Cardiovascular phenotype	2015-07-17	criteria provided, single submitter	clinical testing	Lines of evidence used in support of classification: Synonymous alterations with insufficient evidence to classify as benign
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV000756816	SCV000884736	benign	not provided	2017-05-08	criteria provided, single submitter	clinical testing

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