ClinVar Miner

Submissions for variant NM_017950.4(CCDC40):c.592A>G (p.Met198Val)

gnomAD frequency: 0.00002  dbSNP: rs774843139
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000629279 SCV000750214 uncertain significance Primary ciliary dyskinesia 2021-08-31 criteria provided, single submitter clinical testing This sequence change replaces methionine with valine at codon 198 of the CCDC40 protein (p.Met198Val). The methionine residue is moderately conserved and there is a small physicochemical difference between methionine and valine. This variant is present in population databases (rs774843139, ExAC 0.01%). This variant has not been reported in the literature in individuals affected with CCDC40-related conditions. Algorithms developed to predict the effect of missense changes on protein structure and function output the following: SIFT: "Deleterious"; PolyPhen-2: "Benign"; Align-GVGD: "Class C0". The valine amino acid residue is found in multiple mammalian species, which suggests that this missense change does not adversely affect protein function. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance.

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