Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV002227988 | SCV001380243 | uncertain significance | not provided | 2024-12-12 | criteria provided, single submitter | clinical testing | This sequence change replaces histidine, which is basic and polar, with asparagine, which is neutral and polar, at codon 177 of the GNMT protein (p.His177Asn). This variant is present in population databases (rs121907889, gnomAD 0.07%), and has an allele count higher than expected for a pathogenic variant. This missense change has been observed in individual(s) with glycine N-methyltransferase deficiency (PMID: 11810299). It has also been observed to segregate with disease in related individuals. This variant is also known as p.His176Asn. ClinVar contains an entry for this variant (Variation ID: 4170). Invitae Evidence Modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) indicates that this missense variant is expected to disrupt GNMT protein function with a positive predictive value of 80%. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. |
OMIM | RCV000004387 | SCV000024559 | pathogenic | Glycine N-methyltransferase deficiency | 2002-01-01 | no assertion criteria provided | literature only |