ClinVar Miner

Submissions for variant NM_022039.4(FBXW4):c.457G>A (p.Gly153Arg)

gnomAD frequency: 0.00212  dbSNP: rs116070021
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Eurofins Ntd Llc (ga) RCV000286176 SCV000339369 uncertain significance not provided 2016-02-23 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV003957451 SCV004778819 benign FBXW4-related disorder 2019-07-15 no assertion criteria provided clinical testing This variant is classified as benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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