Total submissions: 3
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Reproductive Endocrine Unit, |
RCV003234544 | SCV003932581 | likely pathogenic | Hypogonadotropic hypogonadism 2 with or without anosmia | 2023-05-04 | criteria provided, single submitter | research | The variant has been classified as LP6 based on the variant meeting the following ACMG Criteria: PM2,PP3,PP1,PP2,PP4. |
Invitae | RCV003764717 | SCV004569619 | uncertain significance | Hypogonadotropic hypogonadism 2 with or without anosmia; Pfeiffer syndrome | 2023-08-25 | criteria provided, single submitter | clinical testing | In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. This variant disrupts the p.Glu692 amino acid residue in FGFR1. Other variant(s) that disrupt this residue have been observed in individuals with FGFR1-related conditions (PMID: 31996231), which suggests that this may be a clinically significant amino acid residue. Advanced modeling of protein sequence and biophysical properties (such as structural, functional, and spatial information, amino acid conservation, physicochemical variation, residue mobility, and thermodynamic stability) performed at Invitae indicates that this missense variant is expected to disrupt FGFR1 protein function. ClinVar contains an entry for this variant (Variation ID: 50851). This missense change has been observed in individual(s) with FGFR1-related conditions (PMID: 23643382). This variant is not present in population databases (gnomAD no frequency). This sequence change replaces glutamic acid, which is acidic and polar, with glycine, which is neutral and non-polar, at codon 692 of the FGFR1 protein (p.Glu692Gly). |
OMIM | RCV000043590 | SCV000071608 | risk factor | Hypogonadotropic hypogonadism 2 with anosmia | 2013-05-02 | no assertion criteria provided | literature only |