ClinVar Miner

Submissions for variant NM_024006.5(VKORC1):c.106G>T (p.Asp36Tyr) (rs61742245)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
OMIM RCV000002296 SCV000022454 pathogenic Warfarin response 2008-02-01 no assertion criteria provided literature only
PharmGKB RCV000211202 SCV000268371 drug response warfarin response - Dosage 2016-06-22 reviewed by expert panel curation PharmGKB Level of Evidence 2A: Annotation for a variant-drug combination that qualifies for level 2B where the variant is within a VIP (Very Important Pharmacogene) as defined by PharmGKB. The variants in level 2A are in known pharmacogenes, so functional significance is more likely.

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