ClinVar Miner

Submissions for variant NM_024006.6(VKORC1):c.*134G>A (rs7294)

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Total submissions: 4
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
PharmGKB RCV000211278 SCV000268386 drug response warfarin response - Dosage 2017-12-11 reviewed by expert panel curation PharmGKB Level of Evidence 1B: Annotation for a variant-drug combination where the preponderance of evidence shows an association. The association must be replicated in more than one cohort with significant p-values, and preferably will have a strong effect size.
PharmGKB RCV000211362 SCV000268387 drug response acenocoumarol response - Dosage 2015-08-19 reviewed by expert panel curation PharmGKB Level of Evidence 2A: Annotation for a variant-drug combination that qualifies for level 2B where the variant is within a VIP (Very Important Pharmacogene) as defined by PharmGKB. The variants in level 2A are in known pharmacogenes, so functional significance is more likely.
PharmGKB RCV000211189 SCV000268388 drug response phenprocoumon response - Dosage 2015-08-19 reviewed by expert panel curation PharmGKB Level of Evidence 2A: Annotation for a variant-drug combination that qualifies for level 2B where the variant is within a VIP (Very Important Pharmacogene) as defined by PharmGKB. The variants in level 2A are in known pharmacogenes, so functional significance is more likely.
Illumina Clinical Services Laboratory,Illumina RCV000295118 SCV000396617 benign Vitamin K-Dependent Clotting Factors 2016-06-14 criteria provided, single submitter clinical testing

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