Submissions for variant NM_024426.6(WT1):c.181C>A (p.Arg61=)

gnomAD frequency: 0.00270  dbSNP: rs2234581

Total submissions: 18

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Invitae	RCV000229054	SCV000290746	benign	Drash syndrome; Frasier syndrome; Wilms tumor 1; 11p partial monosomy syndrome	2024-01-31	criteria provided, single submitter	clinical testing
PreventionGenetics, part of Exact Sciences	RCV000250947	SCV000314311	benign	not specified		criteria provided, single submitter	clinical testing
Illumina Laboratory Services, Illumina	RCV000259336	SCV000371512	likely benign	Meacham syndrome	2018-04-24	criteria provided, single submitter	clinical testing	This variant was observed as part of a predisposition screen in an ostensibly healthy population. A literature search was performed for the gene, cDNA change, and amino acid change (where applicable). No publications were found based on this search. Allele frequency data from public databases allowed determination this variant is unlikely to cause disease. Therefore, this variant is classified as likely benign.
Illumina Laboratory Services, Illumina	RCV000319093	SCV000371513	likely benign	Wilms tumor 1	2018-04-24	criteria provided, single submitter	clinical testing	This variant was observed as part of a predisposition screen in an ostensibly healthy population. A literature search was performed for the gene, cDNA change, and amino acid change (where applicable). No publications were found based on this search. Allele frequency data from public databases allowed determination this variant is unlikely to cause disease. Therefore, this variant is classified as likely benign.
Illumina Laboratory Services, Illumina	RCV000373790	SCV000371514	likely benign	Nephrotic syndrome, type 4	2018-04-24	criteria provided, single submitter	clinical testing	This variant was observed as part of a predisposition screen in an ostensibly healthy population. A literature search was performed for the gene, cDNA change, and amino acid change (where applicable). No publications were found based on this search. Allele frequency data from public databases allowed determination this variant is unlikely to cause disease. Therefore, this variant is classified as likely benign.
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV001668399	SCV001159614	benign	not provided	2023-11-08	criteria provided, single submitter	clinical testing
Women's Health and Genetics/Laboratory Corporation of America, LabCorp	RCV000250947	SCV001370590	benign	not specified	2020-05-30	criteria provided, single submitter	clinical testing
GeneDx	RCV001668399	SCV001883532	benign	not provided	2018-09-28	criteria provided, single submitter	clinical testing
Genetic Services Laboratory, University of Chicago	RCV000250947	SCV002072269	benign	not specified	2020-08-19	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV002243919	SCV002515096	benign	Drash syndrome	2021-12-05	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV002243918	SCV002515098	benign	Frasier syndrome	2021-12-05	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV000259336	SCV002515099	benign	Meacham syndrome	2021-12-05	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV000373790	SCV002515100	benign	Nephrotic syndrome, type 4	2021-12-05	criteria provided, single submitter	clinical testing
Genome-Nilou Lab	RCV000319093	SCV002515101	benign	Wilms tumor 1	2021-12-05	criteria provided, single submitter	clinical testing
Genome Diagnostics Laboratory, The Hospital for Sick Children	RCV002294090	SCV002587389	benign	Focal segmental glomerulosclerosis	2020-05-01	criteria provided, single submitter	clinical testing
Color Diagnostics, LLC DBA Color Health	RCV003588602	SCV004360963	benign	Nephroblastoma	2022-09-16	criteria provided, single submitter	clinical testing
Clinical Genetics Laboratory, Department of Pathology, Netherlands Cancer Institute	RCV000250947	SCV001906192	benign	not specified		no assertion criteria provided	clinical testing
Genome Diagnostics Laboratory, University Medical Center Utrecht	RCV001668399	SCV001928384	likely benign	not provided		no assertion criteria provided	clinical testing