ClinVar Miner

Submissions for variant NM_024426.6(WT1):c.27G>A (p.Pro9=)

gnomAD frequency: 0.00001  dbSNP: rs556835183
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Total submissions: 5
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000862080 SCV001002524 likely benign Drash syndrome; Frasier syndrome; Wilms tumor 1; 11p partial monosomy syndrome 2023-10-19 criteria provided, single submitter clinical testing
Sema4, Sema4 RCV002255550 SCV002530520 likely benign Hereditary cancer-predisposing syndrome 2021-03-23 criteria provided, single submitter curation
Fulgent Genetics, Fulgent Genetics RCV002507467 SCV002809257 likely benign Aniridia 1; Drash syndrome; Frasier syndrome; Meacham syndrome; Mesothelioma, malignant; Nephrotic syndrome, type 4; Wilms tumor 1; 11p partial monosomy syndrome 2022-03-29 criteria provided, single submitter clinical testing
CeGaT Center for Human Genetics Tuebingen RCV003389834 SCV004129977 likely benign not provided 2023-03-01 criteria provided, single submitter clinical testing WT1: BP4, BP7
PreventionGenetics, part of Exact Sciences RCV004549922 SCV004791776 likely benign WT1-related disorder 2023-01-27 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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