ClinVar Miner

Submissions for variant NM_024426.6(WT1):c.367T>G (p.Ser123Ala)

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Ambry Genetics RCV002754724 SCV003748288 uncertain significance Inborn genetic diseases 2021-06-18 criteria provided, single submitter clinical testing The c.352T>G (p.S118A) alteration is located in exon 1 (coding exon 1) of the WT1 gene. This alteration results from a T to G substitution at nucleotide position 352, causing the serine (S) at amino acid position 118 to be replaced by an alanine (A). Based on insufficient or conflicting evidence, the clinical significance of this alteration remains unclear.
All of Us Research Program, National Institutes of Health RCV004009556 SCV004839589 uncertain significance Wilms tumor 1 2023-12-01 criteria provided, single submitter clinical testing

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