ClinVar Miner

Submissions for variant NM_024426.6(WT1):c.75C>T (p.Ser25=)

gnomAD frequency: 0.00001  dbSNP: rs1417997475
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV000653821 SCV000775711 likely benign Drash syndrome; Frasier syndrome; Wilms tumor 1; 11p partial monosomy syndrome 2023-09-20 criteria provided, single submitter clinical testing
PreventionGenetics, part of Exact Sciences RCV004547828 SCV004709080 likely benign WT1-related disorder 2023-06-30 no assertion criteria provided clinical testing This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).

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