Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Pittsburgh Clinical Genomics Laboratory, |
RCV004784946 | SCV005397217 | uncertain significance | Neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures | 2022-09-03 | criteria provided, single submitter | clinical testing | This sequence variant is a single nucleotide substitution (T>G) at coding nucleotide 1267 of the IRF2BPL gene which results in a tyrosine to aspartic acid acid amino acid change at residue 423 in the IRF2BPL protein. This is a novel variant which has not been reported in clinical genetics databases or observed in the medical literature in individuals with IRF2BPL-related disease, to our knowledge. This variant is absent from the gnomAD control population dataset (0/~282000 alleles). Multiple bioinformatic tools predict that this protein change is likely to be damaging, and tyrosine is highly conserved at this protein position in vertebrates. Functiol studies testing the effects of this variant have not been performed, to our knowledge. At this time, there is insufficient evidence to determine if this variant is pathogenic or benign. Therefore, we consider it to be a variant of uncertain significance. ACMG Criteria: PM2, PP3 |