Total submissions: 1
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Labcorp Genetics |
RCV000700432 | SCV000829186 | uncertain significance | Combined oxidative phosphorylation defect type 27 | 2021-07-09 | criteria provided, single submitter | clinical testing | This sequence change results in a premature translational stop signal in the CARS2 gene (p.Trp550*). While this is not anticipated to result in nonsense mediated decay, it is expected to delete the last 15 amino acids of the CARS2 protein. This variant is present in population databases (rs375213252, ExAC 0.003%). This variant has not been reported in the literature in individuals with CARS2-related disease. Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may create or strengthen a splice site, but this prediction has not been confirmed by published transcriptional studies. The current clinical and genetic evidence is not sufficient to establish whether loss-of-function variants in CARS2 cause disease. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance. |