ClinVar Miner

Submissions for variant NM_024675.4(PALB2):c.109-2A>T

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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Myriad Genetics, Inc. RCV003450443 SCV004188411 likely pathogenic Familial cancer of breast 2023-09-06 criteria provided, single submitter clinical testing This variant is considered likely pathogenic. This variant occurs within a consensus splice junction and is predicted to result in abnormal mRNA splicing of either an out-of-frame exon or an in-frame exon necessary for protein stability and/or normal function.
Baylor Genetics RCV003450443 SCV004202617 likely pathogenic Familial cancer of breast 2023-05-31 criteria provided, single submitter clinical testing

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