Submissions for variant NM_024675.4(PALB2):c.1685-14T>A

gnomAD frequency: 0.00001  dbSNP: rs780772404

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000443095	SCV000532690	likely benign	not specified	2016-10-07	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Labcorp Genetics (formerly Invitae), Labcorp	RCV000663142	SCV003468288	likely benign	Familial cancer of breast	2025-01-07	criteria provided, single submitter	clinical testing
Myriad Genetics, Inc.	RCV000663142	SCV004019192	uncertain significance	Familial cancer of breast	2023-03-30	criteria provided, single submitter	clinical testing	This variant is classified as a variant of uncertain significance as there is insufficient evidence to determine its impact on protein function and/or cancer risk.
Color Diagnostics, LLC DBA Color Health	RCV003584602	SCV004357908	likely benign	Hereditary cancer-predisposing syndrome	2022-09-20	criteria provided, single submitter	clinical testing
Department of Pathology and Laboratory Medicine, Sinai Health System	RCV005355771	SCV005920672	likely benign	PALB2-related cancer predisposition	2023-11-24	criteria provided, single submitter	clinical testing
Counsyl	RCV000663142	SCV000786289	likely benign	Familial cancer of breast	2018-04-10	no assertion criteria provided	clinical testing	This submission and the accompanying classification are no longer maintained by the submitter. For more information on current observations and classification, please contact [e-mail].