Total submissions: 2
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Fulgent Genetics, |
RCV001535854 | SCV001752467 | likely pathogenic | Asphyxiating thoracic dystrophy 4; Nephronophthisis 12 | 2021-06-30 | criteria provided, single submitter | clinical testing | |
Labcorp Genetics |
RCV003771652 | SCV004591333 | likely pathogenic | Jeune thoracic dystrophy; Nephronophthisis | 2024-01-04 | criteria provided, single submitter | clinical testing | This sequence change affects an acceptor splice site in intron 23 of the TTC21B gene. It is expected to disrupt RNA splicing. Variants that disrupt the donor or acceptor splice site typically lead to a loss of protein function (PMID: 16199547), and loss-of-function variants in TTC21B are known to be pathogenic (PMID: 18327258, 21068128, 21258341, 23559409, 24876116, 25492405, 27491411, 29068549). This variant is present in population databases (rs779472675, gnomAD 0.002%). This variant has not been reported in the literature in individuals affected with TTC21B-related conditions. ClinVar contains an entry for this variant (Variation ID: 1179039). Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may disrupt the consensus splice site. In summary, the currently available evidence indicates that the variant is pathogenic, but additional data are needed to prove that conclusively. Therefore, this variant has been classified as Likely Pathogenic. |