Total submissions: 4
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Knight Diagnostic Laboratories, |
RCV001270133 | SCV001449007 | pathogenic | Charcot-Marie-Tooth disease axonal type 2X | 2018-06-22 | criteria provided, single submitter | clinical testing | |
Invitae | RCV000034205 | SCV004296957 | pathogenic | Hereditary spastic paraplegia 11 | 2023-07-28 | criteria provided, single submitter | clinical testing | This sequence change affects a donor splice site in intron 18 of the SPG11 gene. It is expected to disrupt RNA splicing. Variants that disrupt the donor or acceptor splice site typically lead to a loss of protein function (PMID: 16199547), and loss-of-function variants in SPG11 are known to be pathogenic (PMID: 19105190, 20110243, 22154821, 26556829). This variant is not present in population databases (gnomAD no frequency). Disruption of this splice site has been observed in individual(s) with hereditary spastic paraplegia (PMID: 19513778, 28119845; Invitae). In at least one individual the data is consistent with being in trans (on the opposite chromosome) from a pathogenic variant. ClinVar contains an entry for this variant (Variation ID: 41304). Algorithms developed to predict the effect of sequence changes on RNA splicing suggest that this variant may disrupt the consensus splice site. For these reasons, this variant has been classified as Pathogenic. |
Gene |
RCV000034205 | SCV000058143 | not provided | Hereditary spastic paraplegia 11 | no assertion provided | literature only | ||
Department of Rehabilitation Medicine, |
RCV000034205 | SCV000882770 | pathogenic | Hereditary spastic paraplegia 11 | 2019-02-11 | no assertion criteria provided | research | The proband has another variant, NM_025137.3: c.5410_5411del (p.Cys1804Profs*25). |