Submissions for variant NM_032119.4(ADGRV1):c.463A>G (p.Ile155Val)

gnomAD frequency: 0.00221  dbSNP: rs199873924

Total submissions: 6

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	RCV000039586	SCV000063275	benign	not specified	2012-04-30	criteria provided, single submitter	clinical testing	Ile155Val in Exon 05 of GPR98: This variant is not expected to have clinical sig nificance because it has been identified in 0.7% (23/3260) of African American c hromosomes from a broad population by the NHLBI Exome Sequencing Project (http:/ /evs.gs.washington.edu/EVS).
Eurofins Ntd Llc (ga)	RCV000039586	SCV000341006	likely benign	not specified	2016-05-26	criteria provided, single submitter	clinical testing
Illumina Laboratory Services, Illumina	RCV001154050	SCV001315370	benign	Usher syndrome type 2C	2025-04-08	criteria provided, single submitter	clinical testing
Labcorp Genetics (formerly Invitae), Labcorp	RCV001516861	SCV001725220	benign	not provided	2025-02-03	criteria provided, single submitter	clinical testing
GeneDx	RCV001516861	SCV001845038	benign	not provided	2019-01-14	criteria provided, single submitter	clinical testing
PreventionGenetics, part of Exact Sciences	RCV004549467	SCV004726951	likely benign	ADGRV1-related disorder	2019-08-29	no assertion criteria provided	clinical testing	This variant is classified as likely benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).