ClinVar Miner

Submissions for variant NM_032634.4(PIGO):c.2943T>A (p.Asp981Glu)

dbSNP: rs1829350572
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Total submissions: 1
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Labcorp Genetics (formerly Invitae), Labcorp RCV001042555 SCV001206241 uncertain significance Hyperphosphatasia with intellectual disability syndrome 2 2021-08-25 criteria provided, single submitter clinical testing This sequence change replaces aspartic acid with glutamic acid at codon 981 of the PIGO protein (p.Asp981Glu). The aspartic acid residue is weakly conserved and there is a small physicochemical difference between aspartic acid and glutamic acid. This variant is not present in population databases (ExAC no frequency). This variant has not been reported in the literature in individuals affected with PIGO-related conditions. Algorithms developed to predict the effect of missense changes on protein structure and function output the following: SIFT: "Tolerated"; PolyPhen-2: "Benign"; Align-GVGD: "Class C0". The glutamic acid amino acid residue is found in multiple mammalian species, which suggests that this missense change does not adversely affect protein function. In summary, the available evidence is currently insufficient to determine the role of this variant in disease. Therefore, it has been classified as a Variant of Uncertain Significance.

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