Submissions for variant NM_033360.4(KRAS):c.5-11A>G

gnomAD frequency: 0.00008  dbSNP: rs369047577

Total submissions: 4

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
GeneDx	RCV000423187	SCV000513429	likely benign	not provided	2016-10-03	criteria provided, single submitter	clinical testing	This variant is considered likely benign or benign based on one or more of the following criteria: it is a conservative change, it occurs at a poorly conserved position in the protein, it is predicted to be benign by multiple in silico algorithms, and/or has population frequency not consistent with disease.
Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine	RCV000825179	SCV000966453	likely benign	not specified	2018-04-06	criteria provided, single submitter	clinical testing	c.451-11A>G in intron 4 of KRAS: This variant is not expected to have clinical s ignificance because it does not alter an amino acid residue and is not located w ithin the splice consensus sequence. Computational tools do not predict an impac t on splicing. It has been identified in 12/124590 European chromosomes by the G enome Aggregation Database (gnomAD, http://gnomad.broadinstitute.org; dbSNP rs36 9047577). ACMG/AMP Criteria applied: BS1_Supporting; BP4.
Labcorp Genetics (formerly Invitae), Labcorp	RCV002061415	SCV002486265	likely benign	RASopathy	2023-08-02	criteria provided, single submitter	clinical testing
ARUP Laboratories, Molecular Genetics and Genomics, ARUP Laboratories	RCV000423187	SCV004563521	likely benign	not provided	2023-11-03	criteria provided, single submitter	clinical testing