Total submissions: 4
Submitter | RCV | SCV | Clinical significance | Condition | Last evaluated | Review status | Method | Comment |
---|---|---|---|---|---|---|---|---|
Medical Genetics, |
RCV000021143 | SCV001245119 | pathogenic | X-linked Alport syndrome | 2020-03-11 | criteria provided, single submitter | clinical testing | |
Labcorp Genetics |
RCV001381887 | SCV001580461 | pathogenic | not provided | 2023-01-26 | criteria provided, single submitter | clinical testing | For these reasons, this variant has been classified as Pathogenic. This variant disrupts the p.Gly129 amino acid residue in COL4A5. Other variant(s) that disrupt this residue have been observed in individuals with COL4A5-related conditions (PMID: 8738805, 9195222), which suggests that this may be a clinically significant amino acid residue. This variant disrupts the triple helix domain of COL4A5. Glycine residues within the Gly-Xaa-Yaa repeats of the triple helix domain are required for the structure and stability of fibrillar collagens (PMID: 7695699, 8218237, 19344236). In COL4A5, missense variants at these glycine residues are significantly enriched in individuals with disease (PMID: 23720012, 27627812) compared to the general population (ExAC). Algorithms developed to predict the effect of missense changes on protein structure and function are either unavailable or do not agree on the potential impact of this missense change (SIFT: "Deleterious"; PolyPhen-2: "Not Available"; Align-GVGD: "Class C0"). ClinVar contains an entry for this variant (Variation ID: 24265). This missense change has been observed in individual(s) with Alport syndrome (PMID: 20378821). This variant is not present in population databases (gnomAD no frequency). This sequence change replaces glycine, which is neutral and non-polar, with arginine, which is basic and polar, at codon 129 of the COL4A5 protein (p.Gly129Arg). |
Fulgent Genetics, |
RCV000021143 | SCV002799709 | pathogenic | X-linked Alport syndrome | 2021-12-24 | criteria provided, single submitter | clinical testing | |
Natera, |
RCV000021143 | SCV002081361 | pathogenic | X-linked Alport syndrome | 2017-06-22 | no assertion criteria provided | clinical testing |