Submissions for variant NM_058216.3(RAD51C):c.-26C>T

gnomAD frequency: 0.18608  dbSNP: rs12946397

Total submissions: 8

Submitter	RCV	SCV	Clinical significance	Condition	Last evaluated	Review status	Method	Comment
Illumina Laboratory Services, Illumina	RCV000381874	SCV000404313	likely benign	Fanconi anemia	2016-06-14	criteria provided, single submitter	clinical testing
Illumina Laboratory Services, Illumina	RCV000269140	SCV000404314	likely benign	Breast and Ovarian Cancer Susceptibility	2016-06-14	criteria provided, single submitter	clinical testing
GeneDx	RCV001712111	SCV001945697	benign	not provided	2015-03-03	criteria provided, single submitter	clinical testing
Breakthrough Genomics, Breakthrough Genomics	RCV001712111	SCV005211125	likely benign	not provided		criteria provided, single submitter	not provided
Leiden Open Variation Database	RCV001195004	SCV001365235	likely benign	not specified	2014-11-02	no assertion criteria provided	curation	Curator: Arleen D. Auerbach. Submitter to LOVD: Christine Rappaport.
Clinical Genetics Laboratory, Department of Pathology, Netherlands Cancer Institute	RCV001195004	SCV001905896	benign	not specified		no assertion criteria provided	clinical testing
Joint Genome Diagnostic Labs from Nijmegen and Maastricht, Radboudumc and MUMC+	RCV001195004	SCV001953522	benign	not specified		no assertion criteria provided	clinical testing
PreventionGenetics, part of Exact Sciences	RCV004544583	SCV004795890	benign	RAD51C-related disorder	2022-09-09	no assertion criteria provided	clinical testing	This variant is classified as benign based on ACMG/AMP sequence variant interpretation guidelines (Richards et al. 2015 PMID: 25741868, with internal and published modifications).