ClinVar Miner

Submissions for variant NM_058216.3(RAD51C):c.-3G>A

dbSNP: rs864622151
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Invitae RCV000204823 SCV000259475 uncertain significance Fanconi anemia complementation group O 2015-07-18 criteria provided, single submitter clinical testing
Ambry Genetics RCV003165489 SCV003861285 uncertain significance Hereditary cancer-predisposing syndrome 2023-02-14 criteria provided, single submitter clinical testing The c.-3G>A variant is located in the 5' untranslated region (5’ UTR) of the RAD51C gene. This variant results from a G to A substitution 3 bases upstream from the first translated codon. This nucleotide position is well conserved in available vertebrate species. Since supporting evidence is limited at this time, the clinical significance of this alteration remains unclear.

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