ClinVar Miner

Submissions for variant NM_058216.3(RAD51C):c.1026+1G>C

dbSNP: rs1567817516
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Total submissions: 2
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Submitter RCV SCV Clinical significance Condition Last evaluated Review status Method Comment
Myriad Genetics, Inc. RCV004027345 SCV004932551 likely pathogenic Breast-ovarian cancer, familial, susceptibility to, 3 2024-01-03 criteria provided, single submitter clinical testing This variant is considered likely pathogenic. This variant occurs within a consensus splice junction and is predicted to result in abnormal mRNA splicing of either an out-of-frame exon or an in-frame exon necessary for protein stability and/or normal function.
German Consortium for Hereditary Breast and Ovarian Cancer, University Hospital Cologne RCV000785444 SCV000924016 likely pathogenic Ovarian neoplasm 2018-12-01 no assertion criteria provided research

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